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Efficacy and safety of sofosbuvir/velpatasvir in patients with chronic hepatitis C virus infection receiving opioid substitution therapy: Analysis of Phase 3 ASTRAL trials

  1. Jordan J. Feld9
  1. 1The Kirby Institute, UNSW Australia, Sydney, NSW, Australia
  2. 2Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
  3. 3Portsmouth Hospitals NHS Trust, Portsmouth, UK
  4. 4Brownlee Centre, Glasgow, UK
  5. 5Gilead Sciences, Inc., Foster City, California, USA
  6. 6Queen Mary University London, London, UK
  7. 7Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
  8. 8Johns Hopkins University, Baltimore, Maryland, USA
  9. 9Toronto Centre for Liver Disease, Toronto, Ontario, Canada
  1. Corresponding author: Jason Grebely, PhD, Associate Professor, Viral Hepatitis Clinical Research Program, The Kirby Institute, UNSW Australia. Phone: +61-2-9385 0957, Fax: +61-2-9385 0876, email: jgrebely{at}kirby.unsw.edu.au
  1. Alternate corresponding author: Jordan J Feld, MD, Assistant Professor, Toronto Centre for Liver Disease, Toronto, Ontario, Canada. Phone: +1-416 603 6230, Fax: +1-416 603 5472, email: jordan.feld{at}uhn.ca

Abstract

In this post-hoc analysis of the Phase 3 ASTRAL trials [non-opioid substitution therapy (OST), n=984; OST, n=51] evaluating the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for HCV infection, OST did not impact completion, adherence, sustained virologic response (SVR12), or safety. SVR12 was 96% (95% CI 87%, >99%) in those receiving OST.

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